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How COVID-19 Causes Loss of Smell
Olfactory support cells, not neurons, are vulnerable to novel coronavirus infection
By MGH NEWS AND PUBLIC AFFAIRS | 13 Aug 2021 14:14PM
Temporary loss of smell, or anosmia, is the main neurological symptom and one of the earliest and most commonly reported indicators of COVID-19. Studies suggest it better predicts the disease than other well-known symptoms such as fever and cough, but the underlying mechanisms for loss of smell in patients with COVID-19 have been unclear. Now, an international team of researchers led by neuroscientists at Harvard Medical School has identified the olfactory cell types in the upper nasal cavity most vulnerable to infection by SARS-CoV-2, the virus that causes COVID-19. Surprisingly, sensory neurons that detect and transmit the sense of smell to the brain are not among the vulnerable cell types...